Lamotrigine after corpus callosotomy

Corpus callosotomy (CC) has been employed in the management of intractable epilepsy since 1940’ and should be considered for patients with generalized falling seizures with physical injury, recurrent life-threatening generalized convulsive status epilepticus or atypical absence status’. CC is especially useful in improving seizure control in patients with tonic and atonic seizures3 and those with a frontal lobe focus’. Tonic seizures are often resistant to standard medical therapy, but there have been a number of reports of the efficacy of lamotrigine (LTG) in this seizure type5-‘. The present report is of five patients who received lamotrigine following a partial or total CC.